DESCRIPTION Maropitant is a Neurokinin (NK1) receptor antagonist that blocks the pharmacological action of substance P in the central nervous system (CNS). Maropitant is the unregistered designation for a substitute for quinuclidine. The empirical formula is C32H40N20 C6H8O7 H20 and its molecular weight is 678.81. The chemical name is (2S, 3S)-2-benzhydryl-N • ( 5 -ter ? butyl -2 - methoxybenzyl ) quinocludin -3 ? amine citrate monohydrate. Each ml of Cerenia® contains 10 mg of Maropitant. INDICATIONS Cerenia® (maropitant citrate) is indicated for the prevention and treatment of acute nausea and vomiting in dogs and for the treatment of vomiting in cats. DOSAGE/ADMINISTRATION SUBCUTANEOUS Administer Cerenia® Injectable Solution subcutaneously at 1 mg/Kg equal to 1 ml/10 Kg of body weight once a day for up to 5 consecutive days. Use at refrigerated temperatures may reduce the painful response associated with injection. Cerenia® Injectable Solution is recommended for use in dogs 8 weeks of age or older, as well as cats 16 weeks of age or older. INFORMATION FOR YOUR USE If vomiting persists despite treatment, the case should be re-evaluated. Cerenia® is very effective in preventing chemotherapy-associated vomiting if administered before the chemotherapeutic agent. In dogs, Cerenia® Injectable Solution can be used interchangeably with Cerenia® tablets, dosing once a day for the prevention of acute vomiting.
CONTRAINDICATIONS The safety of Cerenia® has not been evaluated in dogs or cats used for breeding, or in pregnant or lactating females. The safety of Cerenia® has not been tested in dogs or cats with intestinal obstruction, or that have consumed toxins. Use with caution in patients with liver dysfunction because Cerenia® is metabolized by CYP3A enzymes. Use cautiously with other drugs that are highly protein bound. The concomitant use of Cerenia® with other protein-bound drugs has not been studied in dogs or cats. Drugs that are commonly protein-bound include NSAIDs, cardiac, anticonvulsant, and behavioral medications. The influence of concomitant drugs that may inhibit the metabolism of Cerenia® has not been evaluated. Compatibility with other drugs should be monitored in patients requiring adjunctive therapy. Cerenia® Dosage may cause decreased appetite and body weight. To maximize the therapeutic potential of Cerenia®, the underlying cause of vomiting must be identified and addressed in dogs receiving Cerenia®.
PRECAUTIONS / WARNINGS Do not use in humans. Keep out of the reach of children and pets. In some individuals, topical exposure may cause local allergic skin reactions. Repeated or prolonged exposure may cause skin sensitivity. In case of accidental skin exposure, wash with soap and water. Cerenia® is also an eye irritant. In case of accidental eye exposure, wash with water for 15 minutes and seek medical help. In case of accidental injection or exposure, seek medical help. In puppies less than 11 weeks of age, there is histological evidence of bone marrow cell hypoplasia observed more frequently in puppies treated with Cerenia® compared to control puppies. In puppies older than 16 weeks, bone marrow cell hypoplasia was not observed.
STORAGE It should be stored at controlled room temperature 20°-25° C (68°-77° F) with a range for transport between 15°-30° C (59-86° F). After the first puncture, Cerenia® Injectable Solution should be stored at refrigerated temperature 2° to 8° C (36° - 46° F). Use within 90 days after the first puncture of the vial. The cap should be punctured a maximum of times. Put all waste materials in a plastic bag and seal it before throwing it away. Consult the Veterinary Doctor.